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Human Protein Atlas
pbmc scrnaseq dataset Pbmc Scrnaseq Dataset, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/result/pbmc scrnaseq dataset/product/Human Protein Atlas Average 90 stars, based on 1 article reviews
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10X Genomics
human pbmc scrna-seq data ![]() Human Pbmc Scrna Seq Data, supplied by 10X Genomics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/result/human pbmc scrna-seq data/product/10X Genomics Average 90 stars, based on 1 article reviews
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tissue-matched 3k pbmc scrna-seq dataset ![]() Tissue Matched 3k Pbmc Scrna Seq Dataset, supplied by 10X Genomics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/result/tissue-matched 3k pbmc scrna-seq dataset/product/10X Genomics Average 90 stars, based on 1 article reviews
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10X Genomics
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Image Search Results
Journal: Nature Genetics
Article Title: Mapping interindividual dynamics of innate immune response at single-cell resolution
doi: 10.1038/s41588-023-01421-y
Figure Lengend Snippet: a , Schematic of in vivo system, COVID-19 study of PBMCs and nasal brushings to confirm the splicing QTL association in the OAS1 gene. b , Locus zoom plots show the COVID-19 GWAS (COVID-19 versus population) association Bayes factors as well as eQTL associations of the OAS1 gene in fibroblasts and PBMCs. c , UMAP shows the expression levels of the OAS1 gene in fibroblasts. UMAP coordinates are identical to Fig. . d , UMAP shows the eQTL effect size of the OAS1 gene at rs10774671 G>A. UMAP coordinates are identical to Fig. . e , UMAP shows OAS1 expression level in PBMCs. UMAP coordinates are identical to Extended Data Fig. . f , UMAP shows the eQTL effect size of the OAS1 gene at rs10774671 G>A in PBMCs. UMAP coordinates are identical to Extended Data Fig. . g , Sequencing coverage depth around the splicing variant rs10774671 G>A, which creates three different isoforms, two of which are not annotated in Ensembl 90. scRNA-seq reads in fibroblasts were aggregated and stratified by the three different genotype groups (GG, reference homozygote; GA, heterozygote; AA, alternative homozygote). h , The 10x RNA-seq coverage depth of epithelial cells around OAS1 3′ end in nasal brushing samples taken from 33 COVID-19-positive adult patients was stratified and aggregated by the three genotype groups of rs10774671 G>A as demonstrated in g . UCL, University College London.
Article Snippet: We used
Techniques: In Vivo, Expressing, Sequencing, Variant Assay, RNA Sequencing
Journal: Nature Genetics
Article Title: Mapping interindividual dynamics of innate immune response at single-cell resolution
doi: 10.1038/s41588-023-01421-y
Figure Lengend Snippet: a . UMAP shows the 18 different cell types annotated previously in the PBMC data . b . UMAP shows the secondary response pseudotime calculated from the secondary response genes discovered in the fibroblast data. c . Locus zoom plot shows the COVID-19 GWAS, OAS1 and OAS3 eQTL (both in fibroblasts) associations. UMAP coordinates are identical to Extended Data Fig. 7a. d . UMAP shows the OAS3 gene expression. UMAP coordinates are identical to Fig. . e . UMAP shows the eQTL effect size at rs10774671. UMAP coordinates are identical to Fig. . f . Effect directions of OAS1/3 eQTLs and the risk allele of COVID-19 GWAS at the lead variant rs10774671.
Article Snippet: We used
Techniques: Gene Expression, Variant Assay